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Effects of Environmental Degradation on Genetic Integrity

Author(s) Dr. Naadir Kamal, Azra Kamal, Md. Matloob Raza Khan
Country India
Abstract Gene-environment interactions play a crucial role in determining susceptibility to various diseases, as genetic variations influence individual responses to environmental factors. This paper explores how exposure to ozone, air pollution, pesticides, and ionizing radiation affects human health by altering gene expression and inducing genetic damage. Ozone exposure is linked to respiratory diseases such as asthma and COPD, with genetic polymorphisms in oxidative stress and inflammatory genes modifying individual risk. Fine particulate air pollution (PM2.5) has been associated with an increased risk of Autism Spectrum Disorder (ASD), particularly in genetically predisposed individuals. Pesticides contribute to genetic hazards by disrupting detoxification mechanisms, leading to DNA damage and increased risk of neurological disorders such as Parkinson’s disease. The effects of radiation exposure on genomes have been extensively studied in both human and plant populations exposed to nuclear disasters, medical radiation, and environmental contamination. Ionizing radiation exposure results in genomic instability, mutations, and increased cancer risks, as observed in populations affected by nuclear accidents. Cytogenetic biomonitoring studies have demonstrated the significance of chromosomal aberrations, micronuclei formation, and sister chromatid exchanges as biomarkers of genetic damage due to environmental pollutants. The National Center for Toxicogenomics (NCT) aims to enhance understanding of environmental toxicology through genomic technologies. Given the growing impact of environmental pollutants on genetic health, multidisciplinary research in environmental genomics is essential for developing protective measures, early detection methods, and effective policy interventions to mitigate genetic hazards.
Keywords Gene-environment interactions, genomic instability, chromosomal aberrations, genetic hazards and environmental contamination.
Field Biology > Genetics / Molecular
Published In Volume 16, Issue 2, April-June 2025
Published On 2025-04-04
Cite This Effects of Environmental Degradation on Genetic Integrity - Dr. Naadir Kamal, Azra Kamal, Md. Matloob Raza Khan - IJSAT Volume 16, Issue 2, April-June 2025. DOI 10.71097/IJSAT.v16.i2.3224
DOI https://doi.org/10.71097/IJSAT.v16.i2.3224
Short DOI https://doi.org/g9drdz
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