International Journal on Science and Technology

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Nanomedicine In Cancer Therapy: Targeted Approach For Improved Efficacy

Author(s) Nutan Pagar, Nilesh Shewale, Pankaj Patil, Sanket Jadhav, Mayur Gangurde
Country India
Abstract Nanomedicine has revolutionized cancer therapy by enabling targeted drug delivery, improved therapeutic efficacy, and reduced systemic toxicity. This review explores the latest advancements in nanomedicine for cancer treatment, focusing on targeted approaches such as passive, active, and stimuli-responsive drug delivery systems. Passive targeting exploits the enhanced permeability and retention (EPR) effect, while active targeting utilizes ligand-functionalized nanoparticles for precise tumor recognition. Stimuli-responsive nanocarriers further enhance selectivity by triggering drug release in response to Ph, redox conditions, temperature, or enzymes. Additionally, recent innovations such as nanoparticle-based immunotherapy, combination therapy, and theranostic nanoplatforms have significantly improved treatment outcomes. Despite these advancements, challenges such as biocompatibility, large-scale manufacturing, and clinical translation remain obstacles to widespread clinical adoption. Future research should focus on personalized nanomedicine, AI-driven nanoparticle design, and hybrid nanosystems to enhance efficacy and accelerate clinical integration.
Keywords Targeted Drug Delivery, Stimuli-responsive Nanocarriers, Cancer Nanotheranostics, Nanoparticle Based Immunotherapy, Personalized Nanomedicine
Field Medical / Pharmacy
Published In Volume 16, Issue 1, January-March 2025
Published On 2025-03-31
Cite This Nanomedicine In Cancer Therapy: Targeted Approach For Improved Efficacy - Nutan Pagar, Nilesh Shewale, Pankaj Patil, Sanket Jadhav, Mayur Gangurde - IJSAT Volume 16, Issue 1, January-March 2025. DOI 10.71097/IJSAT.v16.i1.3138
DOI https://doi.org/10.71097/IJSAT.v16.i1.3138
Short DOI https://doi.org/g9dgpn
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