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Hepatoprotective Effect of the Santalum Album Linn. Seeds Against High Fat Diet Induced Non-alcoholic Fatty Liver Disease in Wistar Rats

Author(s) Anchal Rani, Ruhani, Shivani Rangarh, Ashish Kumar
Country India
Abstract Abstract: Non-alcoholic fatty liver disease (NAFLD) has become a significant global health concern, primarily due to poor dietary habits, such as high-fat diets, which contribute to liver dysfunction. This study investigates the hepatoprotective effects of Santalum album Linn. seeds in a high-fat diet-induced NAFLD model in Wistar rats. The rats were divided into several groups, including a normal control group, a high-fat diet-induced NAFLD group, and treatment groups administered with Santalum album seed extracts. Liver function was assessed through biochemical parameters such as serum liver enzymes (ALT, AST, ALP), lipid profiles, and histopathological analysis. Additionally, oxidative stress markers, including malondialdehyde (MDA) and antioxidant enzyme activities, were measured. Results showed that treatment with Santalum album seed extract significantly reduced serum liver enzyme levels, improved lipid profiles, and ameliorated liver histology. The antioxidant properties of Santalum album seeds were found to play a key role in mitigating oxidative stress, a major contributor to liver injury in NAFLD. These findings suggest that Santalum album Linn. seeds possess potential hepatoprotective effects and may be a promising natural therapeutic option for managing NAFLD induced by high-fat diets. Further clinical studies are recommended to validate these results in human populations.
Keywords Keywords: Santalum album, hepatoprotective, non-alcoholic fatty liver disease, high-fat diet, oxidative stress, Wistar rats.
Published In Volume 16, Issue 1, January-March 2025
Published On 2025-01-18
Cite This Hepatoprotective Effect of the Santalum Album Linn. Seeds Against High Fat Diet Induced Non-alcoholic Fatty Liver Disease in Wistar Rats - Anchal Rani, Ruhani, Shivani Rangarh, Ashish Kumar - IJSAT Volume 16, Issue 1, January-March 2025. DOI 10.71097/IJSAT.v16.i1.1415
DOI https://doi.org/10.71097/IJSAT.v16.i1.1415
Short DOI https://doi.org/g82pb6
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