International Journal on Science and Technology

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Faecal transplantation in epilepsy patients.

Author(s) Pooja shukla, Dr.Muzzafar annaev, Dr.Bhabi Jeslina John viji beula
Country India
Abstract Faecal microbiota transplantation [FMT] is a process of collecting faeces from a healthy individual and transplanting it to a patient with gut dysbiosis. FMT has been used for Clostridium difficile infections for years now. Gut microbial flora is a very crucial part of our physiology as gut dysbiosis directly affects the organs. Connection or relationship between gut and nervous system is known as the gut - brain axis, which is partly indicated by epileptic seizures. It is roughly estimated that 30% of patients who have epilepsy, their seizure can’t be controlled by anti-epileptic drugs [1]. Hence when we perform FMT , it helps resolve the imbalance of the gut flora, as a result the seizure threshold also increases , which means that the stimulus needed for the seizure to occur decreases, in turn reducing the count of seizures as a whole. Ketogenic diet is recommended along with FMT for better results, as indirect effects and metabolites of this diet have a positive and a needed effect on epileptic patients. According to various faecal analysis, there is variation in the type of microbes in each disease; hence when we perform a FMT we need to prioritise which microbe is more important and more beneficial for that particular disease.
Keywords Faecal microbiota transplantation; epilepsy; gut - brain axis ; ketogenic diet ; gut microbes
Field Medical / Pharmacy
Published In Volume 16, Issue 1, January-March 2025
Published On 2025-01-13
Cite This Faecal transplantation in epilepsy patients. - Pooja shukla, Dr.Muzzafar annaev, Dr.Bhabi Jeslina John viji beula - IJSAT Volume 16, Issue 1, January-March 2025. DOI 10.71097/IJSAT.v16.i1.1404
DOI https://doi.org/10.71097/IJSAT.v16.i1.1404
Short DOI https://doi.org/g82pb7
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