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Improvement of Griseofulvin's Solubility and Dissolving Characteristics using Nano Crystallization

Author(s) Langari Naresh, B Venkata Phani Deepthi
Country India
Abstract In the present study an attempt has been made to develop nanocrystals of Griseofulvin in order to enhance solubility and dissolution rate by decreasing particle size of drug.The results of compatibility studies by Infrared spectroscopy showed no interaction between the drug and stabilizers.The Griseofulvin nanocrystals were successfully prepared by emulsion solvent diffusion method using different concentrations of stabilizers.The presence of stabilizers made the nanocrystal formulations more stable with increasing drug release.Particle size analyzer used to explore the particle size of Griseofulvin nanocrystals showed a suitable particle size in the range of 80.3nm to 300.6 nm.The polydispersity index of selected nanocrystal formulations(F3C, F3D, F3E, F4D, and F4E) was less than 0.5, which indicated a narrow size distribution of particles. Zeta potential value of Griseofulvin nanocrystals showed a negative surface charge (-19.7mV to -24.7mV). In vitro release study of all the formulations were showed a increased drug release with increase in concentration of different stabilizers. Dissolution rate of all the formulations were improved when compared to pure drug. On the basis of drug release data F3C, F3D, F3E, F4D, and F4E showed a good release profile with more than 80% in 2 hours. The solubility of selected formulations (F3C, F3D, F3E, F4D, and F4E) in phosphate buffer pH(6.8) increased ten folds when compared to pure drug. SEM studies confirmed the morphology of the nanocrystal formulations. The crystalline state of the nanocrystal formulation was not altered according to the XRPD analysis. it was concluded that nanocrystallization was a good approach to enhance the dissolution property of Griseofulvin by emulsion solvent diffusion method. The solubility and in vitro dissolution studies suggested that the nanocrystal formulations can improve the bioavailability of the Griseofulvin by improving its solubility and dissolution rate when compared to pure drug. Thus nanocrystal drug delivery system can adopted to increase the solubility and dissolution rate of poorly soluble drug like Griseofulvin to enhance their bioavailability.
Keywords Formulation, Evaluation, Griseofulvin, Nanoparticles
Field Medical / Pharmacy
Published In Volume 16, Issue 1, January-March 2025
Published On 2025-01-06
Cite This Improvement of Griseofulvin's Solubility and Dissolving Characteristics using Nano Crystallization - Langari Naresh, B Venkata Phani Deepthi - IJSAT Volume 16, Issue 1, January-March 2025. DOI 10.71097/IJSAT.v16.i1.1315
DOI https://doi.org/10.71097/IJSAT.v16.i1.1315
Short DOI https://doi.org/g82pcv
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