A Review on Blood Brain Barriers Receptor

Mr. Somnath Laxman Lokhande; Dr. Amol Navanath Khedkar; Prof. Ms. Sujata Umakant Veer; Prof. Ms. Neha Sunil Garud

doi:10.71097/IJSAT.v15.i4.1230

A Review on Blood Brain Barriers Receptor

Author(s)	Mr. Somnath Laxman Lokhande, Dr. Amol Navanath Khedkar, Prof. Ms. Sujata Umakant Veer, Prof. Ms. Neha Sunil Garud
Country	India
Abstract	The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain–blood interface. We also explained the role of shear stress in maintaining BBB integrity. Furthermore, we elaborated on the clinical aspects that correlate between BBB disruption and different neurological and pathological conditions. Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood–brain barrier, which allow these vessels to tightly regulate the movement of ions, molecules, and cells between the blood and the brain. This precise control of CNS homeostasis allows for proper neuronal function and also protects the neural tissue from toxins and pathogens, and alterations of these barrier properties are an important component of pathology and progression of different neurological diseases. The physiological barrier is coordinated by a series of physical, transport, and metabolic properties possessed by the endothelial cells (ECs) that form the walls of the blood vessels, and these properties are regulated by interactions with different vascular, immune, and neural cells. Understanding how these different cell populations interact to regulate the barrier properties is essential for understanding how the brain functions during health and disease.
Keywords	Blood–brain barrier, Brain diseases, Neurovascular unit
Field	Biology
Published In	Volume 15, Issue 4, October-December 2024
Published On	2024-12-20
Cite This	A Review on Blood Brain Barriers Receptor - Mr. Somnath Laxman Lokhande, Dr. Amol Navanath Khedkar, Prof. Ms. Sujata Umakant Veer, Prof. Ms. Neha Sunil Garud - IJSAT Volume 15, Issue 4, October-December 2024. DOI 10.71097/IJSAT.v15.i4.1230
DOI	https://doi.org/10.71097/IJSAT.v15.i4.1230
Short DOI	https://doi.org/g82pdk

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A Review on Blood Brain Barriers Receptor

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