A New Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Bempedoic Acid and Ezetimibe in Pharmaceutical Dosage Form

Ravindar Bairam; G. Navya; Manjunath S.Y; P. Balakrishanaiah

doi:10.71097/IJSAT.v16.i1.1202

A New Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Bempedoic Acid and Ezetimibe in Pharmaceutical Dosage Form

Author(s)	Ravindar Bairam, G. Navya, Manjunath S.Y, P. Balakrishanaiah
Country	India
Abstract	A straightforward, Accurate, specific approach was created for the concurrent assessment of the Ezetimibe and Bempedoic Acid in pharmaceutical dimension structure. Chromatogram was experienced Inertial ODS C185 m (4.6 x 250mm). Portable phase having Phosphate support and also Acetonitrile in the percentage of 30:70 was siphoned through segment at a stream pace of 1ml/min. Cradle made use of at pH 4.6. Temperature was stayed on top of at Ambient. Boosted regularity for Ezetimibe as well as Bempedoic Acid was 260nm. Maintenance period of Ezetimibe and Bempedoic Acid were considered as 2.395 minutes and also 3.906 min. The percentage merit of Ezetimibe and Bempedoic Acid was considered as 100.6 percentage and also 101.3 percentage independently. The framework appropriateness boundaries for Ezetimibe and also Bempedoic Acid, for example, theoretical plates and complying with element were deemed 1.3, 1012.4 and also 1.2, 1848.2 the objective was viewed as 9.0. The linearity research for Ezetimibe and also Bempedoic Acid was discovered in focus scope of 1μg-5μg as well as 100μg-500μg and also link coefficient (r2) was considered as 0.999 and also 0.999, percentage mean recuperation was considered as 100.1 percentage and 100.4 percentage, percentage RSD for repeatability was0.31 and 0.38, percentage RSD for middle of the road accuracy was 0.12 and 0.15 separately the accuracy study was precise, powerful and repeatable. LOD esteem was 2.94 as well as 3.03, and also LOQ esteem was 9.87 and 10.1 individually.
Keywords	Ezetimibe, Bempedoic Acid, RP-HPLC
Field	Medical / Pharmacy
Published In	Volume 16, Issue 1, January-March 2025
Published On	2025-01-20
Cite This	A New Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Bempedoic Acid and Ezetimibe in Pharmaceutical Dosage Form - Ravindar Bairam, G. Navya, Manjunath S.Y, P. Balakrishanaiah - IJSAT Volume 16, Issue 1, January-March 2025. DOI 10.71097/IJSAT.v16.i1.1202
DOI	https://doi.org/10.71097/IJSAT.v16.i1.1202
Short DOI	https://doi.org/g82pc3

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A New Stability Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Bempedoic Acid and Ezetimibe in Pharmaceutical Dosage Form

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