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Correlation Between Imaging Biomarkers and Laboratory Findings in Psychological Disorders: Bridging the Gap Between Radiology and Mental Health

Author(s) Nourah M. Alorainy, Faisal E. Aljwuaied, Wafa I. Alotaibi, Ali A. Alshehri, Laila M. Alshaikh
Country Saudi Arabia
Abstract Psychological disorders are characterized by complex interactions between structural brain abnormalities and biochemical dysregulations. This cross-sectional study, conducted in a tertiary hospital, investigated the correlation between neuroimaging biomarkers and laboratory findings in 150 patients with major depressive disorder, schizophrenia, and bipolar disorder. Magnetic resonance imaging (MRI) and positron emission tomography (PET) revealed significant gray matter volume reductions in the hippocampus and anterior cingulate cortex, alongside functional connectivity disruptions. Laboratory analyses showed elevated cortisol and interleukin-6 (IL-6) levels, with serotonin levels at the lower end of the normal range. Correlation analysis identified significant relationships between hippocampal gray matter volume and cortisol levels (r=0.65,p=0.003r = 0.65, p = 0.003), anterior cingulate connectivity and IL-6 (r=0.58,p=0.012r = 0.58, p = 0.012), and prefrontal cortex activity and serotonin (r=−0.42,p=0.028r = -0.42, p = 0.028). These findings underscore the value of integrating neuroimaging and laboratory biomarkers to enhance diagnostic precision and inform personalized treatment strategies.
Keywords psychological disorders, neuroimaging biomarkers, laboratory biomarkers, cortisol, IL-6, serotonin, hippocampus, anterior cingulate cortex, personalized medicine
Published In Volume 8, Issue 3, July-September 2017
Published On 2017-07-05
Cite This Correlation Between Imaging Biomarkers and Laboratory Findings in Psychological Disorders: Bridging the Gap Between Radiology and Mental Health - Nourah M. Alorainy, Faisal E. Aljwuaied, Wafa I. Alotaibi, Ali A. Alshehri, Laila M. Alshaikh - IJSAT Volume 8, Issue 3, July-September 2017. DOI 10.5281/zenodo.14500514
DOI https://doi.org/10.5281/zenodo.14500514
Short DOI https://doi.org/g8vqst
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